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doi: 10.1016/B978-0-12-800197-4.00008-7 Bonning, Bryony C., Pal, Narinder, Liu, Sijun, Wang, Zhaohui, Sivakumar, S., Dixon, Philip M., King, Glenn F

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13 The increased burden of reactive oxidants in patients with COPD also derives from leukocytes and macrophages involved in the inflammatory process in the lungs

noted reduced expression of the GHR in the kidneys of 5/6 nephrectomized animals, which was associated with elevated pro-inflammatory cytokines, suggesting that GH-insensitivity in uremia is a general phenomenon and not restricted to the liver and growth plates ( vide supra ) [174]