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Description

REDEFINE 2 showed 13.7% in T2D patients at 68 weeks

Received: Issue date: DOI:

Retrieved Nov 20, 2023

To investigate whether albumin could be engineered to evade L585 cleavage and the resulting reduction in FcRn binding, we constructed a panel of 18 full-length 585-engineered human albumin variants, in which the C-terminal leucine residue was substituted with each of the other naturally occurring amino acids, except for cysteine (Fig