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Most CQDs are rapidly cleared renally, limiting long-term retention, although doped or larger particles may persist in liver, spleen, or tumour tissue [161, 166]

Animal studies examining bone healing have used various administration methods

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In the primary analysis using the trial product estimand, which evaluated participants who adhered to treatment, bodyweight decreased progressively in all active treatment groups over the 26-week period, without clear evidence of reaching a plateau