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This low-grade systemic inflammation: Impairs insulin receptor signalling, directly worsening insulin resistance Damages ovarian granulosa cells, impairing egg development and ovarian function Disrupts gut barrier integrity, contributing to what some researchers call a "leaky gut" pattern associated with systemic inflammation Amplifies HPA axis dysregulation, raising cortisol and further disrupting sex hormone balance Chronic inflammation is both a consequence of PMOS and a driver that perpetuates it

NFE2L1-mediated proteasome function protects from ferroptosis

We also recommend a balanced diet full of fruit and vegetables, particularly sulfur-rich foods such as broccoli, kale, mushrooms, egg, meat, fish, garlic, and onions

29, 244S273S (2010)