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This context-dependent sensitivity to GSH inhibition indicates that the viability of PC cells largely lies in the balance between ROS generation and endogenous antioxidant scavenging capacity

In addition, it has been shown that the expression of cytochrome P450 oxidoreductase (POR), a positive regulator of ferroptosis, is significantly increased in G6PD knockdown hepatocellular carcinoma (HCC) cells, which suggests that G6PD may inhibit ferroptosis through POR (Cao et al., 2021)

The S4 category covering hormone and metabolic modulators is also relevant to GLP-1, GIP, and glucagon receptor agonists generally

M., Patel, A