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If a drug is taken into the gastrointestinal tract (GI tract), where it enters the hepatic portal system through the portal vein, it becomes well-metabolized and is said to show the first pass effect

All non-physician use is considered research.

Technically, the term pernicious anemia refers to a B12 deficiency due to malabsorption caused by atrophic gastritis, due to a lack of intrinsic factor or problems with its secretion due to atrophy of the gastric mucosa, autoimmune attack against the intrinsic factor, and/or autoimmune destruction of the secretory parietal cells (as in the case of atrophic gastritis, also of autoimmune origin, which causes achlorhydria and is secondary to some autoimmune diseases that can predispose to problems in the gastric mucosa)

Arginine is a precursor for the synthesis of proteins, urea, and various signaling molecules [122]