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In a large cohort of active young men, dual users demonstrated significantly poorer performance in cardiorespiratory endurance and muscular fitness tests compared to never users, including slower 2-mile run times and fewer push-ups and sit-ups performed, even after adjusting for physical training habits (82)

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People who smoke their first cigarette more than 30 minutes after waking up must use a 2mg gum, whereas persons who smoke within half an hour after waking up must opt for a 4mg gum