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This can lead to a shorter duration of B12 in the body, increasing the need for supplementation or injections to maintain adequate levels

To evaluate the therapeutic efficacy of LXR inverse agonists in vivo, we used three different dysmetabolic rodent models, including high-fat diet (HFD)-induced obese (DIO) mice, HFD-fed Zucker diabetic fatty (ZDF) rats and HFD-fed SpragueDawley (SD) rats (Extended Data Fig