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Transition metals found in particulate matter are also capable of generating further oxidants through Fenton-like reactions [7]

Overexpression of parkin in mice reduced DA neuronal cell loss induced by MPTP through the protection of mitochondria and the reduction of -syn (Palacino et al., 2004)

This disruption manifests through the decreased expression of genes involved in cholesterol biosynthesis and transport, leading to reduced levels and impaired secretion of ApoE lipoproteins (Valenza et al., 2010