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Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Similarly, Semax , a synthetic peptide with nootropic properties, has been shown to increase brain-derived neurotrophic factor (BDNF) and dopamine function, potentially improving cognitive flexibility and emotional regulation in individuals affected by long-term substance use (Myasoedov et al., 2013)

This theory is gradually popular and accepted in gastrointestinal diseases and was proved by several studies [20, 48, 67]

Johnson, B, Morris, VK, Wang, X, Dasari, NV, Raghav, KS, Shen, JY, Lee, MS, Huey, RW, Parseghian, C, Willis, JA, Wolff, RA, Drusbosky, L, Overman, MJ, Kopetz, S