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Discussion Since the emergence of COVID-19 in 2019, the world has been in a state of contingency to fight the virus, which caused the death of more than 6 million people, and scientists around the world are racing to identify the risk factors associated with the pathogenic mechanism of COVID-19

Impairment of circadian rhythm: the pathophysiological substrate of insomnia associated with alterations of circadian rhythms provides the rationale for melatonin administration in PD

TPOAb titers decreased to varying degrees in patients with different genotypes of the single nucleotide polymorphism r25191G/A, which indicates interindividual differences (75)

Mechanistically, ALA may support lipid metabolism through several pathways:60 Reduces oxidative stress in liver cells ALA works as an antioxidant by neutralizing reactive oxygen species (ROS) unstable molecules that can damage liver cells and interfere with fat metabolism