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People describe symptoms in many different ways, making it difficult to systematically compare social media posts with standardized medical terminology from the Medical Dictionary for Regulatory Activities (MedDRA), which clinicians use to classify symptoms

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The V-ATPase inhibitor bafilomycin A 1 is the most commonly used compound to collapse the lysosomal pH gradient and to block autophagosome-lysosome fusion, thus enabling quantitative measurement of autophagy flux based on accumulated lipidated LC3 23,60