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According to the Hansen family, Hubert Hansen founded a small juice brand, Hansens Naturals, in the 1930s

During pathological conditions, cytokines can also stimulate inducible nitrogen oxide synthase (iNOS) which results in the production of NO in astrocytes and microglial cells (Murphy, 2000), which can then combine with superoxide radicals to form the aforementioned peroxynitrite, facilitating excitotoxicity (Leist et al., 1997) and DNA damage, ultimately leading to cell death (Xia et al., 1996)

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doi: 10.1016/j.plantsci.2007.09.006 13 CostaL.VicenteA