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As regulatory requirements become more stringent and consumer expectations for product quality and transparency continue to rise, the competitive advantage favoring larger, better-capitalized manufacturers is expected to intensify, potentially resulting in further consolidation within the industry

In macrophages, increased HO-1 expression shows the ability to convert mobilized M1 macrophages into alternately activated M2 macrophages with anti-inflammatory effects, which is essential for the wound healing phase [127]