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The target-decoy method was employed to control the FDR at 1% for both peptides and proteins (6870)

Lung cadmium content was determined by inductively coupled plasma-mass spectrometry (ICP-MS) analysis, and TOPO-PMAT QD disposition was modeled using PKSolver as described in Methods

doi: 10.1016/j.jbc.2022.102530 86 GadaletaRMGarcia-IrigoyenOCarielloMScialpiNPeresCVetranoSet al

The treatment arm achieved an 18 percent mean reduction in visceral adipose tissue versus a small increase in placebo, with statistically significant improvements in triglycerides (minus 50 mg/dL), total cholesterol, and patient-reported body image