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Immunofluorescence and Western blotting in SH-SY5Y cells revealed a 4.5-fold reduction in acetylated -tubulin following methamphetamine treatment, which was reversed by11.9-fold upon lactoferrin-CAY10603-PLGA treatment

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These parameters are illustrated schematically in Figure 32 where the volume of the beakers into which the drugs diffuse represents the volume of distribution, and the size of the outflow drain in Figures 32B and 32D represents the clearance