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Choline promotes fat metabolism and prevents hepatic steatosis

T2341018), the High Level Chinese Medical Hospital Promotion Proiect (Project No

The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]

Armstrong JS, Steinauer KK, Hornung B, Irish JM, Lecane P, Birrell GW et al (2002) Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line