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Diffraction data for the C408S and C201S/C408S variants were collected at the BESSY II Lightsource on BL14.1 beamline with a fixed wavelength of 0.918

In contrast, foregoing study has reported that inhibition of p38 MAPK pathway resulted in upregulation of reactive oxygen species, mediating activation of JNK and thereby sensitizing human tumor cells to cisplatin induced apoptosis [82]

Author Contributions HT, APM and JJW conceptualized the studies, HT, APM, AJP and RCG performed the experiments, HT and JJW wrote the original draft of the manuscript, APM, AJP and RCG edited and reviewed the manuscript, and JJW, HT, AJP and APM acquired funding

Invitrogen), 100 units/mL penicillin, and 100 g/mL Streptomycin and stored in a 37C humidified incubator with 5% carbon dioxide