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Research demonstrates that BPC-157 upregulates vascular endothelial growth factor receptor-2 (VEGFR2) at both mRNA and protein levels in endothelial cells without increasing VEGF-A itself, instead sensitizing cells to existing VEGF signaling while simultaneously activating the Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway

Astrocytes in control animals show few, delicate and short processes, whereas already during the first 2 weeks of cuprizone exposure astrocytes display morphological changes and become hypertophic with thick processes

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