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Clin Ther 2011;33:132230 [DOI] [PubMed] [Google Scholar] 3.Fontana RJ

Techniques to Assess DNA Methylation Methylation-Sensitive Restriction Enzymes The methylation status of a DNA sequence can be determined using a variety of techniques such as the use of restriction enzymes (REs), which recognize short DNA sequences and cleave double-stranded DNA at specific sites within or adjacent to these sequences