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Furthermore, the chelation process can occur not only at its carboxyl group to form a four-membered ring but also simultaneously at the hydroxyl and carboxyl groups to form a six-membered ring

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Br J Clin Pharmacol 71:2028 Shayiq RM, Roberts DW, Rothstein K, Snawder JE, Benson W, Ma X, Black M (1999) Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: an explanation for high acetaminophen dosage in humans without hepatic injury

In Parkinson's disease, there is an ~60% reduction in GSH concentration in the substantia nigra of presymptomatic patients 22 , suggesting GSH deficiency as one of the earliest biochemical signs of this disorder