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This group also studied mice with doxorubicin-induced cardiomyopathy and found that ferroptosis played an important role, possibly because doxorubicin upregulates HO-1, releasing free iron and leading to the generation of oxidized lipids in the mitochondrial membrane

This dosage showed the potential to trigger an elevation in the number of mitochondria and upregulation in the expression of the Ucp2 gene, which has a crucial role in regulating the mitochondrial processes associated with energy balance to prevent excessive weight gain

Overall, these results are consistent with BPA acting as a weak ER agonist and are the first to report prolonged estrogenic effects of BPA in retinal tissue