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Sensitization to the cytotoxic effect of topoisomerase-1 inhibitors in BAX transfection of lymphoblastic leukemia

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If PIM1 regulates NRF2, and persister cancer cells are dependent on glutathione 4 peroxidase (GPX4) and methionine extra-supply (transsulfuration pathway), then PIM1 inhibition might serve as a relevant therapeutic strategy