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This region of calreticulin has a low affinity binding site for calcium and contains the KDEL sequence that is believed to be important in retaining the protein within the ER (104)

Nonetheless, the outcomes obtained from in-vitro models of digestion often differ from those observed in in-vivo models, primarily because of the difficulties in accurately simulating the highly intricate physiochemical and physiological processes that take place within the human digestive system [96]

It is always a good idea to consult a doctor before starting any new dietary supplements, particularly if one suffers from existing health problems.

In: Porwitt A, McCullough J and Erber WN eds