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The Cox17 Located in the IMS transfers cytoplasmic copper to the IMS, delivering it to CcO synthase (Sco1/2) and Cox11, respectively, both of which insert copper ions into CcO[18,19]

Schmidt et al., 2013)

In line with this, a recent ex vivo study in 6 weeks bile-duct ligated (BDL) rats showed that a rise in lactate (1.7 fold) and not glutamine is an important player in the pathogenesis of brain edema in CLF [39]