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Conditions affecting any stage of this absorption pathwayincluding pernicious anaemia (an autoimmune condition destroying intrinsic factor-producing cells), Crohn's disease, coeliac disease, or surgical removal of stomach or ileal tissuecan significantly impair B12 absorption despite its water-soluble properties

Repeated apnea and intermittent hypoxia cause NAD(P)H oxidase (Nox)-dependent ROS production, wherein most of the ROS are superoxide anion that further activates phospholipase C, resulting in the activation of calmodulin kinase C (CaMK) and protein kinase C [8, 68]

Conversely, UVA leads to collagen degradation and apoptosis in dermal fibroblasts, with limited direct effects on melanocyte number or morphology 10,12

X., Wang, X., Fam, J., & Kim, J