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GATEWAY TO FAILURE: Whether the result is negative health consequences or addiction, it appears that the common denominator in many of these problems is the early use of tobacco

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However, it cannot be excluded that except for nicotine, chemicals like acrolein and methyl vinyl ketone, present in TS and e-cigs have been shown to cause oxidative stress by the generation of ROS through activation of protein kinase C via NADPH oxidase (Asano et al., 2012)