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Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys

Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 ( Chac1 ), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

As diabetes is associated with alterations in the microbial profiles and reduced diversity, microbiome may contribute to the severity and progression of the disease (Vrieze et al., 2012