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Indications: resulting either from organic heart disease or from cardiac surgical procedures inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility Contraindications: Patients with idiopathic hypertrophic subaortic stenosis (IHSS) and in patients who have shown previous manifestations of hypersensitivity to dobutamine Patients with IHSS have an asymmetric septal hypertrophy resulting in a dynamic left ventricular outflow obstruction (LVOT)

The handful of studies sometimes cited as human evidence are largely case reports or small, uncontrolled pilot studies

HRH3 gene: Histamine receptor 3 is important in regulating histamine levels in the brain

Expert Rev Anti Infect Ther 2011