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A reduction in CHAC2 expression disrupts the cell cycle and leads to cell death, highlighting its importance in early development processes (Wang et al., 2017)

furthermore, preeclamptic dams injected with these regenerated extensive placental vascularity ( In a different investigation, it was shown that EXOs miR-139-5p from HUCMSCs-EXOs accelerated trophoblast invasion and migration, activated the ERK/MMP-2 pathway, and blocked trophoblast apoptosis by decreasing protein tyrosine phosphatase expression, all of which improved PE manifestations in rats (Liu et al., 2020b)