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Wow, I don't know where I got my information but way back when I started injecting I read that the half-life is 7 hours...which explains why some have to dose so often

Metformin-related vitamin B12 deficiency occurs as metformin causes reduced vitamin B12 absorption by interfering with the vitamin B12-intrinsic factor complex

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the compound class is promising as a research platform for metabolic-disease biology and combinatorial strategies with diet or NAD precursor approaches