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Kondoh Y, Kawase M, Hirata M, Ohmori S

More hydrophilic conjugates would be expected to display a decreased binding to plasma proteins, but published investigations suggested that a change in plasma protein binding was dependent on the polyphenol and its type and position of conjugation ( TABLE 3 Degree of phase II conjugation of compounds detected in serum/plasma after intake of Pycnogenol and plasma protein binding of Pycnogenol constituents and metabolites

Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation

Upregulated expression of a transcription factor or enhanced binding to gene promoters enhances the transactivation efficiency