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7 Discussion Dementia, as a neurodegenerative disease, exhibits a high incidence rate and a prolonged disease course, imposing substantial psychological and economic burdens on patients and their families (Ayhan et al., 2023)

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Recent improvements have increased its potential: Fast and efficient way for pre screening stable knockouts In species where stable transformation is feasible but time-consuming, VIGS provides a rapid means to identify interesting candidate genes before generating stable knockout lines