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Moreover, the proteolytic activity of the proteasome requires catalysis by the intact sulfhydryl groups of Cys residues in the subunit of the 20S core, which is susceptible to oxidative stress [26]

Role in Inflammatory Bowel Disease Inflammatory bowel diseases (IBD), including Crohns disease (CD) and ulcerative colitis (UC), is a multifactorial, chronic immune-mediated disease of the GI tract that results from a complex interaction between environmental, genetic and epigenetic risk factors that cause an inappropriate mucosal immune response leading to intestinal inflammation

The function and structure of Tau depends on the cellular environment as well as the post translational modifications [10]

Jiangxi J Tradit Chin Med 2022;53:124