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Mechanistically, we present the first direct evidence of a transcriptional negative regulatory relationship between Stat1 and Nrf2, with Crizotinib promoting this transcriptional activity, suggesting that inhibiting Stat1 could offer an intriguing intervention strategy

ZOs are peripherally associated proteins that interact with claudins, occludins, and JAMs to anchor the membrane proteins, tethering them to the actin cytoskeleton [10, 16]

A variety of different enzymes utilize glutathione in a variety of biotransformations [1]

16 Subsequently, it was discovered that antioxidant supplementation (e }_c^-\) is sufficient to trigger ferroptosis in vitro