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In support of the role of Kupffer cells in carbon-tetrachloride-induced hepatic damage, it was reported that gadolinium chloride (10 mg/kg given intravenously 24 h before carbon tetrachloride administration) prevented and methyl palmitate, another Kupffer cell inhibitor, attenuated the periportal oedema observed using proton magnetic imaging 1-2 h after carbon tetrachloride administration (0.8 ml/kg given intraperitoneally) (Towner et al., 1994)

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These approaches reflect different physical properties of the liver to characterize liver tissue microstructure 55