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This observation is not only true for C34 and C37 mAbs but is also consistent with several prior studies

This involves: Starting allopurinol or febuxostat at a low dose with gradual titration upward Regular monitoring of uric acid levels to confirm target is being reached Prophylactic medication to prevent flares during the titration period Ongoing lifestyle modification guidance and support Periodic review to assess for tophi resolution, joint damage, and overall progress Treatment Success Rates The evidence for gout treatment effectiveness is strong across all approaches: Acute attack relief there is no clear superiority between NSAIDs and colchicine for treating acute gout attacks

However, despite the excellent catalytic performance of noble metal nanozymes, their low clearance rate and potential accumulation in circulation and tissues remain the main challenges in long-term biosafety studies [30]