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On another side, the RNS, mainly the peroxynitrite (ONOO ) interact with guanine to generate oxidative and nitrative DNA damage such as 8-oxodeoxyguanosine and 8-nitroguanine, respectively (Phaniendra et al., 2015)

Gene expression of a truncated and the full-length growth hormone (GH) receptor in subcutaneous fat and skeletal muscle in GH-deficient adults: impact of GH treatment