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and (3) smooth wage index differences across adjacent local areas

Aging Cell Neelakantan et al

Anemia may be due to fluid retention, occult or gross GI blood loss, or an incompletely described effect on erythropoiesis

Iron chelation - Apart from regular blood transfusions, iron chelation therapy in the form of deferoxamine (desferal) subcutaneous infusion (with a pump), oral tablets like deferiprone (kelfer), deferasirox (few common brands are asunra, desirox, defrijet or oleptiss) is required as the excess iron from blood transfusions accumulate in the vital organs causing severe damage and even death due to cardiac and liver failure