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They reduce hydrogen peroxide and organic hydroperoxides to water or alcohols by oxidizing GSH to GSSG

In addition to the above benefits, studies have found wide ranging positive effects including reducing blood pressure, blood sugar and inflammation, though some of these have not yet been rigorously investigated

Novel concepts of regulation such as epigenetic modifications (DNA methylation, histone acetylation), post-translational modifications of autophagy proteins (ubiquitination, phosphorylation), and interactions with other stress-response pathways such as ferroptosis or ER stress remain underexplored but may prove critical in determining whether autophagy serves as a pro-survival or pro-death mechanism

Mental Health Comorbidity in MS: Depression, Anxiety, and Bipolar Disorder