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10.1080/19490976.2021.1994833 146 ZhongH.ZhangH.HuY.HeS.QuH.HeJ.et al (2023)

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4 Evidence suggests that frataxin deficiency inhibits mitochondrial respiration and promotes production of reactive oxygen species (ROS), causing mitochondrial dysfunction, oxidative stress and subsequent mitochondrial iron accumulation

Following sublingual administration, Drug A is 100 % bioavailable while following rectal administration, Drug A bioavailability is between 40 and 100 %, depending how far up the rectum the drug product is inserted Measurement of Bioavailability For intravenous injection, the whole of drug dose is delivered directly into the systemic circulation, thus it will always have 100 % bioavailability (F = 1) and the maximal plasma concentration (C max ) is reached instantaneously (T max = 0 min)