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TB-500 was initially studied for its ability to regenerate heart tissue after heart attacks

Hypoxia-inducible factor-1 confers resistance to the glycolytic inhibitor 2-deoxy-D-glucose

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

These decisions will play a critical role in determining whether peptide therapies move closer to mainstream clinical use or remain in a more limited regulatory position