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Bipolar disorder: A landmark RCT (n=75) found that NAC (1,000 mg twice daily for 24 weeks) produced a significant improvement in depression scores (Montgomery-Asberg Depression Rating Scale) in bipolar disorder as an adjunct to usual treatment (Berk et al., Biol Psychiatry, 2008) [74]

Administration methods for contacting macrophages are well known in the art, particularly because macrophages are commonly present in various tissue types (see Ries et al (2014) Cancer Cell 25: 846-859

Sapkota Y, Low SK, Attia J, Gordon SD, Henders AK, Holliday EG, MacGregor S, Martin NG, McEvoy M, Morris AP, Takahashi A et al (2015) Association between endometriosis and the interleukin 1A (IL1A) locus