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The increase in plasma homocysteine concentration in this study was marginal at 0.6 mol/L, and the causal relationship between hyperhomocysteinemia and adverse health outcomes is still uncertain 40,41

Yankaskas, C

Furthermore, inspired by our recent discovery that oxirane warheads, when attached to KRAS G12D -targeting ligands, could simultaneously covalently modify KRAS G12C and KRAS G12D 53 , we also included this warhead in our study