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15 16 Sermorelin, under the brand name Geref, was FDA-approved for pediatric growth hormone deficiency but was later taken off the market for non-medical reasons

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An additional mode of communication from the gut to the brain includes the enteric nervous system (ENS) and sensory neurons expressing receptors to TNF-, IL-1 or IL-6 (243), and to 5-HT (244), which is abundantly produced at the gut level (245) (upwards black arrows in Figure 2 )