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12 These outcomes are consistent with a maintained postprandial metabolic effect but note the important confound: in these trials cagrilintide is almost always studied with semaglutide, so cleanly attributing the postprandial glucose benefit to cagrilintides gastric or glucagon effects specifically is not straightforward

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Dose reduction community sources describe halving the per-injection dose when flushing or metallic taste becomes too intrusive, then re-evaluating at 2 weeks