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Description

Betaine increases the level of secretory immunoglobulin A (sIgA), which plays an important role in the clearance of pathogens and harmful substances, and also up-regulates IL-4 and down-regulated TNF- in small intestinal mucosa (216)

Furthermore, a subsequent study showed that these exosomes reduced the proportion of polymorphonuclear granulocytic bone marrow-derived suppressor cells (G-MDSCs, CD11b + Ly6G + ) and monocytic myeloid-derived suppressor cells (M-MDSCs, CD11b + Ly6C + ), while significantly increased the proportion of DCs (CD45 + CD11c + )

A critical mechanistic insight is that these stimuli share a common pathway: they enhance ROS production in neutrophils, which then activates MAPK signaling to upregulate PAD4