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It was clinically approved by both the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) in 2014 for the treatment of relapsing-remitting multiple sclerosis (MS), showing a significant efficacy over 2 years versus placebo and a favorable benefit-risk profile in two phase-III clinical trials, although with several adverse effects such as nausea, diarrhea, abdominal pain and leukopenia in some patients [282, 283]

65) and KG1a 66 leukemia cell lines were obtained from the German Collection of Microorganisms and Cell Cultures (DSMZ)

Deciphering the causes of sporadic late-onset cerebellar ataxias: a prospective study with implications for diagnostic work

Per sample, 36 cardiac MTs or 54 hepatic MTs were used in order to obtain sufficient amounts of RNA for sequencing