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Review 2026 (Springer Inflammopharmacology, DOI 10.1007/s10787-025-01882-z) confirmed its cytoprotective effect on the digestive tract with oral doses ranging from 10 to 50 g/kg

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Abbreviations ACD: Accidental cell death ACSL4: Acyl-CoA synthetase long-chain family member 4 AD: Alzheimers disease ART: Artesunate ATP: Adenosine triphosphate CYP: Cytochrome P450 DAMP: Damage-associated molecular pattern DFO: Deferoxamine DFP: Deferiprone DFX: Deferasirox DMT1: Divalent metal transporter 1 D-PUFA: Deuterated polyunsaturated fatty acid phospholipid DXR: Dexrazoxane EC: Epicatechin ECG: Epicatechin-3-gallate EDTA: Ethylenediamine tetra-acetic acid EGC: Epigallocatechin EGCG: Epigallocatechin-3-gallate ETC: Electron transport chain FDA: Food and Drug Administration FPN: Ferroportin FTH1: Ferritin heavy chain 1 FTL1: Ferritin light chain 1 GPX4: Glutathione peroxidase 4 GSH: Glutathione HCP1: Heme carrier protein 1 HD: Huntingtons disease HRG-1: Heme responsive gene-1 IRP: Iron regulatory protein KRAS: Kirsten rat sarcoma viral oncogene homolog LIP: Labile iron pool LOX: Lipoxygenase MDA: Malondialdehyde MDS: Myelodysplastic syndrome mRNA: Messenger RNA NADPH: Nicotinamide adenine dinucleotide phosphate NCOA4: Nuclear receptor coactivator 4 NFKB: Nuclear factor kappa B NO: Nitric oxide NOX: NADPH oxidases NTBI: Non-transferrin bound iron PCD: Programed cell death PD: Parkinsons disease PUFA: Polyunsaturated fatty acids RCD: Regulated cell death ROS: Reactive oxygen species RSL3: RAS selective lethal 3 SCD: Sickle cell disease SLC3A2: Solute carrier family 3 member 2 SLC7A11/xCT: Solute carrier family 7 member 11 SOD: Superoxide dismutase STAT3: Signal transducer and activator of transcription 3 Tf: Transferrin TfR 1: Tf receptor 1 References Abboud S, Haile DJ (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism

16 Li LT, Jiang G, Chen Q, Zheng JN