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Interestingly, high manganese intake upregulated liver ZIP14 expression in male and female mice but upregulated ZIP14 expression in the small intestine of only male mice

Jrup L, Hellstrm L, Alfvn T (2000) Low-level exposure to cadmium and early kidney damage: the OSCAR study

Bastacky J, Lee CY, Goerke J, Koushafar H, Yager D, Kenaga L, Speed TP, Chen Y, Clements JA: Alveolar lining layer is thin and continuous: Low-temperature scanning electron microscopy of rat lung

In fact, LR3 IGF-1 is most likely eliminated quite fast when administered in vivo due to the fact that it binds less to serum proteins such as IGFBPs